Azathioprine
Posted: 03 Dec 2012, 10:50
Azathioprine
Azathioprine is metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis. A thiopurine methyltransferase (TPMT) test may be needed to look for individuals prone to azathioprine toxicity.
Adverse effects include
•bone marrow depression
•nausea/vomiting
•pancreatitis
A significant interaction may occur with allopurinol and hence lower doses of azathioprine should be used.
Azathioprine is metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis. A thiopurine methyltransferase (TPMT) test may be needed to look for individuals prone to azathioprine toxicity.
Adverse effects include
•bone marrow depression
•nausea/vomiting
•pancreatitis
A significant interaction may occur with allopurinol and hence lower doses of azathioprine should be used.