Azathioprine
Azathioprine is metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis. A thiopurine methyltransferase (TPMT) test may be needed to look for individuals prone to azathioprine toxicity.
Adverse effects include
•bone marrow depression
•nausea/vomiting
•pancreatitis
A significant interaction may occur with allopurinol and hence lower doses of azathioprine should be used.
Azathioprine
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