SLE: investigations

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meme nony
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SLE: investigations

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SLE: investigations

Immunology
•99% are ANA positive
•20% are rheumatoid factor positive
•anti-dsDNA: highly specific (> 99%), but less sensitive (70%)
•anti-Smith: most specific (> 99%), sensitivity (30%)

Monitoring
•ESR: during active disease the CRP is characteristically normal - a raised CRP may indicate underlying infection
•complement levels (C3, C4) are low during active disease (formation of complexes leads to consumption of complement)
•anti-dsDNA titres can be used for disease monitoring (but note not present in all patients)
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