Renal tubular acidosis

[osman blal]

I would like to share you asimple fixed idea about RTA : RTA is acidosis of the blood due to renal tubular defect , in RTA type 1 the defect in distal tubular execretion of H+ lead to acidotic blood and alkaline urine which predispose to stones formation and in RTA type 2 the defect in proximal tubular reabsorption of Hco3 lead to acidotic blood and alkaline urine for awhile because of consuption of total body bicaroponate for this reason the urine will be alkaline firstly then after consuption of HCO3 it will be relatively acidotic hence NO stone in type 2 RTA , In RTA type 4 there is hyporeninamic hypoaldesteronism lead to as we know Na depletion and K retntion and K will be transported inside the cell inversily with H+ lead to acidotic blood , so all RTA cause normal anion gap metabolic acidosis but there is low k+ in RTA type 1 and 2 and high k in RTA type 4
Thanx alot

[osman blal]

in RTA type 1 we don't have problem in HCO3 rebsorption so give it
in RTA type 2 there is a problem and you need to give high dose of HCO3 and also to restrict the volume with diuretics,
in RTA type4 just replace mineralocorticods

Thanx alot

[heyam]

thank you....i was revising it to day ..